Research

My research involves modeling oxygen transport and blood flow regulation in the microcirculation, which is the part of the circulation consisting of the smaller blood vessels that supply oxygen to the majority of surrounding tissue.  I use mathematical and computational models to try to answer questions about how blood flow and blood flow regulation affect tissue oxygenation, in particular in networks of microvessels with heterogeneous structure.

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Publications

2023

17. Verticchio Vercellin A, Siesky B, Antman G, Oddone F, Chang M, Eckert G, Arciero J, Kellner RL, Fry B, Coleman-Belin J, Carnevale C, and Harris A.  “Regional vessel density reduction in the macula and optic nerve head of patients with pre-perimetric primary open angle glaucoma”.  Journal of Glaucoma, 32: 930-941 (2023).  DOI: https://doi.org/10.1097/IJG.0000000000002310 [Link to article]

16. Siesky B, Harris A, Verticchio Vercellin A, Arciero J, Fry B, Eckert G, Guidoboni G, Oddone F, and Antman G.  “Heterogeneity of ocular hemodynamic biomarkers among open angle glaucoma patients of African and European descent”.  Journal of Clinical Medicine, 12 (2023).  DOI: https://doi.org/10.3390/jcm12041287 [Link to article]

15. Albright A, Fry BC, Verticchio A, Siesky B, Harris A, and Arciero J.  “Metabolic blood flow regulation in a hybrid model of the human retinal microcirculation”.  Mathematical Biosciences, 357 (2023).  DOI: https://doi.org/10.1016/j.mbs.2023.108969 [Link to article]

2021

14. Arciero J, Fry B, Albright A, Mattingly G, Scanlon H, Abernathy M, Siesky B, AV Vercellin, and Harris A.  “Metabolic signaling in a theoretical model of the human retinal microcirculation”.  Photonics, 8 (2021).  DOI: 10.3390/photonics8100409 [Link to article]

13. Fry BC and Secomb TW.  “Distinct roles of red-blood-cell-derived and wall-derived mechanisms in metabolic regulation of blood flow”.  Microcirculation, 28: e12690 (2021).  DOI: 10.1111/micc.12690 [Link to article]

2020

12. Fry BC, Harris A, Siesky B, and Arciero J.  “Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina”.  Mathematical Biosciences, 329 (2020).  DOI: 10.1016/j.mbs.2020.108476 [Link to article]

2018

11. Fry BC, Coburn EB, Whiteman S, Harris A, Siesky B, and Arciero J.  “Predicting retinal tissue oxygenation using an image-based theoretical model”.  Mathematical Biosciences 305: 1-9 (2018).  DOI: 10.1016/j.mbs.2018.08.005 [Link to article]

2017

10. Chen Y, Fry BC, and Layton AT.  “Modeling glucose metabolism and lactate production in the kidney”.  Mathematical Biosciences 289: 116-129 (2017).  DOI: 10.1016/j.mbs.2017.04.008 [Link to article]

2016

9. Chen Y, Fry BC, and Layton AT.  “Modeling glucose metabolism in the kidney”.  Bulletin of Mathematical Biology 78: 1318-1336 (2016).  DOI: 10.1007/s11538-016-0188-7 [Link to article]

8. Fry BC, Edwards A, and Layton AT.  “Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: A modeling study”.  American Journal of Physiology – Renal Physiology 310: F237-247 (2016).  DOI: 10.1152/ajprenal.00334.2015 [Link to article]

2015

7. Fry BC, Edwards A, and Layton AT.  “Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration”.  American Journal of Physiology – Renal Physiology 308: F967-980 (2015).  DOI: 10.1152/ajprenal.00600.2014 [Link to article]

6. Sgouralis I, Evans RG, Gardiner BS, Smith JA, Fry BC, and Layton AT.  “Renal hemodynamics, function, and oxygenation during cardiac surgery performed on cardiopulmonary bypass: A modeling study”. Physiological Reports 3: e12260 (2015). DOI: 10.14814/phy2.12260 [Article PDF]

2014

5. Fry BC and Layton AT.  “Oxygen transport in a cross-section of the rat inner medulla: Impact of heterogeneous distribution of nephrons and vessels”.  Mathematical Biosciences 258: 68-76 (2014).  DOI: 10.1016/j.mbs.2014.09.009 [Link to article]

4. Fry BC, Edwards A, Sgouralis I, and Layton AT.  “Impact of renal medullary three-dimensional architecture on oxygen transport”.  American Journal of Physiology – Renal Physiology 307: F263-F272 (2014).  DOI: 10.1152/ajprenal.00149.2014 [Link to article (Editor’s pick)]

2013

3. Fry BC, Roy TK, and Secomb TW.  “Capillary recruitment in a theoretical model for blood flow regulation in heterogeneous microvessel networks”.  Physiological Reports 1: e00050 (2013). DOI: 10.1002/phy2.50 [Article PDF]

2. Fry BC. Theoretical models for blood flow regulation in heterogeneous microvascular networks. Ph.D. Thesis, University of Arizona (2013). [PDF through Arizona Open Repository]

2012

1. Fry BC, Lee J, Smith NP, and Secomb TW.  “Estimation of blood flow rates in large microvascular networks”.  Microcirculation 19: 530-538 (2012). DOI: 10.1111/j.1549-8719.2012.00184.x [Link to article]