Outline-2, BIO 2310, Contraction


A. Neuromuscular Junction = Motor end-plate

1. Motor neuron

2. Neurotransmitter (Acetylcholine)

3. Motor unit

B. Excitation/contraction Coupling=Sliding Filament Theory

1. T Tubules

2. Calcium

Short lived release

3. Myosin

ATP binding site

Actin binding site

4. Troponin and tropomyosin move

5. Myosin

Attaches actin

Moves towards sarcomere center = Power Stroke

C. Regulation; Calcium

D. ATP sources

1. Skeletal muscle

2. Creatine phosphate

3. Aerobic metabolism

4. Anaerobic metabolism (lactic acid)

5. Muscle fatigue

E. Oxygen and Glycogen debt

Neuromuscular Junction Video

Myofilament Contraction Video

Sarcomere Shortening Video

Action Potentials and Muscle Contraction